Why does my depression never seem to get better regardless of what I do?

Name: Deepa Date of Birth: 3 February 1992 Place of Birth: Indore Time: 06:30 AM. I have had depression for years and it seems like nothing ever actually gets better. I've attempted therapy, meds, journaling, exercise, and even spiritual work. An astrologer in my town informed me that my moon is in the 12th house and Saturn is in retrograde, which could be heightening my emotional instability. Some days I feel fine, but then I crash again without reason. It's tiring and demoralizing. Why do certain types of depression defy treatment regardless of how hard you try? Is there something deeper astrological, biochemical, or psychological that I'm overlooking? I want to know why I just can't seem to extricate myself from this vicious cycle.